Given the topic is somewhat complex and has generated confusion, I thought it would be helpful to provide a professional medical opinion on the subject, including the most likely reasons BOTOX may not seem to work. BOTOX resistance is a situation in which a patient either has built up antibodies against the botulinum toxin, or happens to metabolize the BOTOX drug exceptionally quickly.
As a result, for these patients BOTOX injections provide underwhelming results, a very short-lived effect, or no effect at all. Rather, it is one of the following:.
While many patients notice fewer wrinkles in as little as 48 hours, it is normal to take up to 10 days for full effects to realize. In other words, you may need to be patient. If it has been more than 2 weeks and you are still not seeing the results you expect, consult with your provider. Either change can cause lines that were once only bothersome with facial expressions to deepen. Instead, a treatment plan of BOTOX plus injectable fillers to plump up the skin can help you maintain a youthful look and your natural facial expressions.
Less experienced providers are prone to mistakes such as using the wrong dose or injecting in the incorrect point on the facial muscle, both of which can result in underwhelming results or worse. If you have deep lines that are present at rest when you are not using the muscles then you will not be able to get rid of those wrinkles with Botox alone.
Injection of a dermal filler product may be needed to provide further improvement. True Botox resistance is rare. It happens in about 1 out of every 10, cases. The exact cause is not known, but it seems that our immune system forms antibodies against the Botox. A more common occurrence is that some people build tolerance to Botox after repeated use and tend to need increased doses over time. Since the explosion of Botox use , researchers and doctors are realizing that resistance to Botox can develop and, even that there may be some who are completely immune to its effects.
According to a representative from Allergan, the company that makes Botox:. Antibody formation is more of a concern when patients must receive frequent injections or when it is used to treat medical conditions such as cervical dystonia that require higher doses. However, recent long-term studies have indicated immunogenicity to be a minor concern even with that treatment.
To put it plainly, Botox resistance immunity does occur in some patients. If it happens again and you are still determined to have a line-free forehead , try seeing a different doctor. Fortunately, there are options. They are similar to Botox except for subtle differences in their formulation. Sometimes people who did not get an optimal result with Botox seem to respond better to Dysport or Xeomin.
There are a multiple reasons for this. You will not receive any improperly reconstituted or overly diluted Botox, Dysport or Xeomin at Body Tonic.
Do be aware of pricing if you go somewhere else for your neurotoxin, and of course research the establishment and injectors. Deeply discounted product may not be from the manufacturer or may be improperly reconstituted.
They are equally effective products that are simply made by different manufacturers. The active protein in each product is slightly different. It can actually be good practice to switch between all three periodically so your body does not build up antibodies to any one product in particular. When should you see optimal results?
You may not see full effects until days post treatment. The other day I caught myself thinking, My Xeomin didn't work! But then I realized it had only been 4 days since my treatment. Your 2-week follow-up appointment: If you need some tweaking after your treatment, it has to be 10 days post your first appointment. We will not add units before this time.
This is a hard and fast rule. The reasoning for this is, for example, that if we do a touch-up on day 7, the results from your initial treatment are likely still kicking in, and adding Botox when the injector cannot see the full effects means you will be improperly dosed, which can lead to less than optimal results.
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